The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses.
The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart.
Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies.
Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease.
The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.
The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease.
The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact.
The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells.
The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus.
Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets.
The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy.
The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host.
The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children.
Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections.
The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1.
The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates.
The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.
The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease.
The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation.
The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring.
The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work.
Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus.
Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph are circadian - it is dependent on the time of day.
Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood.