Cross-systems youth, or youth who experience homelessness, child welfare involvement, and educational difficulty, often suffer due to lack of continuity and stability in their school and home lives, as well as in service provision. These children are at risk for a number of negative outcomes, which are in part a reflection of the failure of multiple systems. In this episode, three members of the University at Buffalo School of Social Work faculty (Anna Ball, Betsy Bowen, and Annette Semanchin-Jones) engage in a discussion on cross-systems youth. They highlight their research involving the perspectives and experiences of youth and service providers in relation to multiple systems – education, child welfare, and housing and social services – and provide suggestions to improve and promote collaboration.