Prof John Gribben (University London and Barts, London, UK) chairs a discussion for ecancertv at iwCLL 2015 with Prof Michael Hallek (University Clinic of Cologne, Cologne, Germany) Dr Michael Keating (University of Texas MD Anderson Cancer Center, Houston, USA) Prof Kanti Rai (Long Island Jewish Medical Center, New York, USA) about the highlights of iwCLL 2015. They focus on the current and evolving landscape of CLL and potential treatment pathways. They also note the importance of the integration of the Young Investigators Meeting (YIM) within the main iwCLL congress.