AI in clinical practice needs ethical frameworks to avert future biases. In this Q&A, Marzyeh Ghassemi, PhD, the Herman L. F. von Helmholtz Career Development Professor at MIT in Electrical Engineering and Computer Science (EECS), joins JAMA's Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss ethical machine learning and responsible clinical implementation. Related Content: AI Developers Should Understand the Risks of Deploying Their Clinical Tools, MIT Expert Says