Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research. Dr Katie Myers Smith discusses findings from her recent study. Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and Dr Katie Myers Smith responds to questions on her recent research. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the July episode Dr Katie Myers Smith from Queen Mary University of London talks about her team's recent study looking at e-cigarettes versus nicotine replacement therapy (NRT) as a harm reduction intervention for people who smoke and who find quitting difficult. Their randomised controlled study compared e-cigarettes with NRT in 135 people who smoked and who were previously unable to stop smoking with conventional treatments. Dr Myers Smith's study found that in people who smoked and were unable to quit using conventional methods, e-cigarettes were more effective than NRT in facilitating validated long-term smoking reduction and smoking cessation, when limited other support was provided. We will include the results in our Cochrane review. For more information on the study see Myers Smith et al 2021, Addiction, June 2021, DOI: 10.1111/add.15628 . Our July 2021 literature search identified two new included studies (Myers Smith et al 2021, DOI: 10.1111/add.15628 ; Kimber et al 2021 DOI: 10.1016/j.addbeh.2021.106909 ) and two reports linked to studies already in the review (Leavens et al 2021, DOI: 10.1111/add.15597 linked to Pulvers 2020; Jones et al 2021, DOI: 10.1097/ADM.0000000000000881 linked to Klonizakis 2017).