Neal Brennan joins Chelsea to talk about resetting his brain with Ayahuasca and 5-MeO-DMT, whether or not all comedians are clinically depressed, and what it’s like to be the friend of the funny guy.  Then: A girlfriend finds some disturbing threads saved on her boyfriend’s computer.  A 90-day...

Actress and activist Jamie Lynn Sigler joins Chelsea to talk about why it took her so long to accept her MS diagnosis, how going through her “athlete phase” led her to the love of her life, and the unexpected turns her life has taken since her career-defining role on The Sopranos.  Then: A single...