The International Centre for Advanced Science on River-Sea Systems is known as the "Danubius Research Infrastructure".  In reality, it's not about the Danube River, although the scientific idea started in the Danube Delta-Black Sea system, as a Romanian initiative. Then it quickly became an international, pan-European initiative to develop a distributed RI, comprising 13 countries, that seeks sustainable solutions for complex river-sea systems. The waters coming from a river have a strong impact on the sea that receives them, so proper management at a basin-scale needs to look at the way in which the waters, including snow melt, tributaries and ground water, and the activities of humans upstream, impact the coastal waters. Adrian Stanica, Director of the Romanian National Institute for Marine Geology and Geoecology in Budapest, summarises the main problems as water sufficiency, sediments and ecosystem health. The cumulative effects of industrialisation and agriculture, both of which consume water and produce runs-offs, are being exacerbated by climate change. Energy generation in the form of hydroelectric dams is restricting water flows and blocking essential fish migrations, while heavy shipping adds pollutants and Non-indigenous and Invasive Species. There’s pressure from expanding urbanisation, fisheries that demand ever-increasing yields and – with greater leisure time – more and more tourism. Less water and increased sedimentation threaten natural habitats, with loss of biodiversity – which weaken the ecosystem services and functions. Probably 99 percent of all humans live in hydrographic basins, because water is essential, but we are exhausting the systems that give us life. Listen to this "Danubius Research Infrastructure" podcast to understand some of the complex dilemma that we all collectively need to find solutions to.