Andrew (Andy) F. Wiener, PharmD (Twtitter @andywiener) describes the pathogenesis and risk factors of C. diff infection and recurrence, reviews the preferred treatment modalities for prevention of C. diff recurrence and describes the cost-benefit analysis supporting guideline-directed management of C. diff infections. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter! You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.