Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker.  School's out for summer but general practice never stops. This week we look at the medical news story of the week: donanemab for Alzheimer's disease - can this monoclonal antibody revolutionise dementia care? Also in research, prevention is better than a cure, so can a Mediterranean-DASH diet keep cognitive decline at bay? For you weekend warriors out there, is cramming exercise into the weekend as good as exercising throughout the week. A new paper in JAMA answers this question. And is there ANY role for opioids in acute back pain? A new Australian study goes strong to see if there is benefit with this common problem. Don't forget to check out all our upcoming courses including the new Hot Topics course in September and much more on www.nbmedical.com. References JAMA Donanemab NEJM MIND diet for dementia prevention JAMA Weekend warriors and CVD risk Lancet Opioids for Low back and neck pain