Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this episode, we talk to Prof Hazel Everitt, a GP and lead author of a recent Lancet paper exploring whether amitriptyline is effective for IBS, and where it might fit in to general practice management. We also look at research in the Lancet on treating hand osteoarthritis with methotrexate - what's the rationale and does it work? - plus a BMJ paper on using a patient information leaflet to improve lower urinary tract symptoms in men. Are PILS better than pills? Resources Lancet ATLANTIS paper on IBS & amitriptyline ATLANTIS trial website with patient information Gut journal CBT for IBS National Institute for Health and Care Research - how to get involved NIHR Local research groups - how to get involved Lancet Methotrexate for hand OA with synovitis BMJ Leaflets for LUTS www.nbmedical.com/podcast