"Impact of Stress on the Brain: Pathology, Treatment and Prevention," the 2016 issue of Neuropsychopharmacology Reviews, focuses on advances in our understanding of the impact of stress on the brain: From pathology to circuits, treatment to prevention. Emerging data from genetics, epigenetics, neural circuit and intergenerational models, animal models, and neuroimaging all suggest that stress affects the brain in a variety of dynamic and often long-lasting ways. The effects of these processes on developmental risk for pathology are particularly notable. Produced by Nature Publishing Group and featuring Kerry J. Ressler, MD, PhD and Jordan W. Smoller, MD, ScD, this podcast synthesizes a broad array of neuroscience perspectives and approaches, demonstrating with fascinating clarity how the brain, when homeostasis / allostasis is dysregulated through the process of stress (whether external or internal), can lead to emotional dysregulation and behavioral difficulties. Neuropsychopharmacology Reviews: http://www.nature.com/nppr/index.html