This episode covers the 2005 Nobel Prize in Physiology or Medicine, which was awarded to Barry J. Marshall and J. Robin Warren. The Nobel Assembly at the Karolinska Institute chose to give Marshall and Warren the prize “for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease”. Topics include the symptoms associated with gastritis and peptic ulcer disease, Marshall deliberately infecting himself with the bacterium, and current treatments for H. pylori infections.