In our second episode, we discuss the role of skepticism in science, a topic that relates closely to the title of our podcast. Given that the scientific enterprise is essentially an exercise in organized skepticism, how can we maintain a healthy amount of skepticism while also ensuring that scientists don't slip into cynicism or nihilism?    Shownotes Opening quote by Imre Lakatos from Science and Pseudoscience. Hear it from the man himself.  Ego depletion Ioannidis, J. P. (2005). Why most published research findings are false. PLoS Medicine, 2(8), e124. https://doi.org/10.1371/journal.pmed.0020124 Wacholder, S., Chanock, S., Garcia-Closas, M., El Ghormli, L., & Rothman, N. (2004). Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. Journal of the National Cancer Institute, 96(6), 434-442. DOI: 10.1093/jnci/djh075 Quote by Debra Mayo. Original reference: Mayo, D. G. (2018). Statistical inference as severe testing: How to get beyond the statistics wars. Cambridge University Press.