Anton Langerak is Professor and head of Laboratory Medical Immunology at the Department of Immunology, Erasmus MC in Rotterdam, Netherlands and chair of coordination of the EuroClonality-NGS working group (https://euroclonality.org/ngs/about and https://euroclonality.org). He has been working on chronic lymphocytic leukemia (CLL) for many years and in this episode we discuss the signatures of B cell receptors in CLL. AIRR Community Meeting VI: “Exploring New Frontiers”: https://www.antibodysociety.org/the-airr-community/meetings/airr-community-meeting-vi-exploring-new-frontiers Comments are welcome at the inbox of [email protected] or on social media under the hashtag #onAIRR. Further information can be found here: https://www.antibodysociety.org/the-airr-community/airr-c-podcast