Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.20.387738v1?rss=1 Authors: Arslan, A. Abstract: Motivation: The transport of proteins plays a crucial role in the cellular phenotype. Changes in the protein targeting sequence can result in missing protein delivery to the right destination and at the right time, and can disrupt various cellular pathways. Given the importance of single residue change(s) in the protein targeting sequence we developed a missing computational method. Results: By taking into account various protein features like conservation, protein modifications, charge, isoelectric effect and biochemical properties of peptides, the method, TransSite, assess the impact of mutations on the protein transportation. We applied this method to human cancer proteins and discovered several cancer proteins harbour recurring mutations in their targeting sequences. Availability: https://github.com/AhmedArslan/TransSite Contact: [email protected] Supplementary information: Supplementary data are available at # online. Copy rights belong to original authors. Visit the link for more info