Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.06.239277v1?rss=1 Authors: Zhang, W., Xie, C., Ullrich, K. K., Zhang, Y. E., Tautz, D. Abstract: Gene retroposition is known to contribute to patterns of gene evolution and adaptations. However, possible negative effects of gene retroposition remain largely unexplored, since most previous studies have focussed on between-species comparisons where negatively selected copies are mostly not observed, as they are quickly lost from the populations. Here, we show for natural house mouse populations that the primary rate of retroposition is orders of magnitude higher than previously thought. Comparisons with SNP distribution patterns in the same populations show that most retroposition events are deleterious. Transcriptomic profiling analysis shows that new retroposed copies become easily subject to transcription and have an influence on the expression level of their parental genes, especially when transcribed in the antisense direction. Our results imply that the impact of retroposition on the mutational load in natural populations has been highly underestimated, which has also major implications for strategies of disease allele detection in humans. Copy rights belong to original authors. Visit the link for more info