Welcome to PICU Doc On Call, A Podcast Dedicated to Current and Aspiring Intensivists. I'm Pradip Kamat and I'm Rahul Damania. We are coming to you from Children's Healthcare of Atlanta - Emory University School of Medicine. Welcome to our Episode a 15 mo F with respiratory distress and runny nose. Here's the case: A 15 mo F presents to the ED with cough, runny nose, and increased work of breathing. Her mother states that the patient has had these symptoms for the past three days, however, the work of breathing progressed. The patient has had 2 fevers during this course, with the highest 101F. She says that her 3 yo cousin who she visited for the holidays had similar symptoms. Mother notes decreased PO and wet diapers. The patient presented to the ED with the following vital signs: T 38.5C, HR 155, BP 70/48 (MAP 50), RR 48, 92% on RA. The patient on the exam was noted to be tachypneic with abdominal retractions, grunting, and nasal flaring. The patient was nasally suctioned and initiated on 12 L 40% of HFNC. The patient was then transferred to the PICU for further management. To summarize key elements from this case, this patient has: Increased work of breathing indicates respiratory distress. She has a prodrome of symptoms that worsened prior to presentation And a sick contact. All of which brings up a concern for acute respiratory failure requiring non-invasive positive pressure ventilation in the form of HFNC. Let's transition into some history and physical exam components of this case? What are key history features in this child who presents with respiratory distress and URI sx? Usually, children under the age of two with bronchiolitis will present with cough, respiratory distress, and crackles on lung exam. The crackles indicate atelectatic alveoli that are filled with fluid which occurs due to inflammatory processes in the lung triggered by respiratory viruses. Respiratory distress, increased work of breathing, respiratory rate, and oxygenation all can change rapidly with crying, coughing, and agitation. Are there some red-flag symptoms or physical exam components in a child with acute respiratory distress which you could highlight? That is a great question. We really want to highlight the distinction between respiratory distress and respiratory failure. Children with respiratory failure in our case may have issues with oxygenation or ventilation as well as increased work of breathing that necessitates higher levels of respiratory support like HFNC. In a 2003 Journal of Pediatrics study, infants who were most severely affected with bronchiolitis were born prematurely, 12 weeks of age, or who have underlying cardiopulmonary disease or immunodeficiency. These children are at risk for apnea and respiratory failure which may require escalation to mechanical ventilation. Finally, Infants with bronchiolitis may have difficulty maintaining adequate hydration because of increased fluid needs and metabolic demand. Remember these children will have increased insensible losses due to fever and tachypnea, as well as decreased oral intake related to their systemic illness. To continue with our case, the patient's labs were consistent with: Mild hyper NA 149 All other electrolytes were within normal limits. The patient had a respiratory viral panel which was positive for Rhino/Entero and RSV. Her COVID PCR was negative. A CXR was performed and showed alveolar airspace disease consistent with I would like to highlight an important point, with the exception of otitis media, a secondary bacterial infection is uncommon among infants and young children with bronchiolitis. In a nine-year prospective study of 565 children (3 yo) hospitalized with documented RSV infection published in the Journal of Pediatrics, subsequent bacterial pneumonia was present in only 0.9 percent of these. Yes, Rahul, that is a great point. The risk of secondary bacterial pneumonia is...