If you're looking for a hopeful and mind-expanding conversation to round out the year, this one is for you. It's our breakthroughs of the year episode, covering 2023's biggest achievements in science and tech, including space technology, life extension, fusion, gene editing, vaccines, and, of course, GLP-1s. It has become a 'Plain English' tradition—after weeks of stories that often take us into sad areas, like anxiety, depression, and war—to close the year with a nerdy conversation about the most important developments at the frontier of science and technology. Today's frontier guide is Dr. Eric Topol. He is the founder and director of the Scripps Research Translational Institute and a bestselling author on the future of medicine. If you have questions, observations, or ideas for future episodes, email us at [email protected].  Host: Derek Thompson Guest: Eric Topol Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices