Dr Arnold Eiser, MD, MACP trained as a nephrologist over 40 years ago but has come to see that the kidneys, liver and other 'extracranial factors' (influences from outside the cranium, the skull holding the brain) hold some of the most impactful sway over the health of our brains. He's termed this relationship between organ dysfunction in the body to assumed compromise in central nervous system brain neuroinflammation Eiser's Corollary of Related Toxicity. His  book, Preserving Brain Health in a Toxic Age: New insights from neuroscience, integrative medicine and public health  (Rowman & Littlefield, Oct 2021) explores this topic in depth. He examines the ways in which environmental policy, corporate pollutive behavior, metals, microbes, common medications like acetaminophen (Tylenol), and experiences with digital violence seem to hasten neuroinflammatory changes that can present as our current epidemics of autism and Alzheimer's Disease. It's a multi-tiered attack on the nervous system that our society doesn't loop back to true root causes. The book explores the interface between the chemical environment and industrial and agricultural practices.. He notes almost all neurotoxins are also carcinogenics and recognizes the key role of the liver as a front-line organ for protection or vulnerability for brain inflammation- and then notes the epidemic of non-alcoholic fatty acid disease in the modern world. He notes that CFS/ dysautonomia was originally described in the 1800's as a 'disease of modernity' associated with newspaper printing and rail travel. We then talk about the integrative medicine, high fructose corn syrup, nutrients, spices, and in the process really listing out many of the ways we can make our whole world medicine better at preserving brain health. Find the book: https://www.amazon.com/Preserving-Brain-Health-Toxic-Age/dp/1538158078 or https://rowman.com/ISBN/9781538158074/Preserving-Brain-Health-in-a-Toxic-Age-New-Insights-from-Neuroscience-Integrative-Medicine-and-Public-Health