This week we discuss Parkinson’s Disease and single molecule spectroscopy with Dr Derrick Lau, a PostDoc at the University of New South Wales (@UNSW). Single molecular spectroscopy can be used to track the formation and purification of α-synuclein aggregates, a hallmark of PD, and potentially lead to a tool for early diagnosis of Parkinson’s Disease. We discuss how single molecular spectroscopy is transferable to medium throughput and use bio fluids for early diagnosis of Parkinson Disease but also potentially other neurodegenerative diseases. Finally, we discuss preprints, what it it like to apply for PostDocs in a pandemic as well transitioning from immunology and neuroscience.  Read the full preprint - https://www.biorxiv.org/content/10.1101/2021.08.09.455607v1.full Other links Microbiome in PD- https://www.nature.com/articles/s41531-021-00156-z Immunotherapy in PD - https://pubmed.ncbi.nlm.nih.gov/31978602/ α-synuclein in PD patients biofluides - https://pubmed.ncbi.nlm.nih.gov/32444560/ AttoBright - https://www.nature.com/articles/s41467-019-13617-0 https://www.nature.com/immersive/d41586-021-02563-x/index.html This episode was produced by Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).