Those in the business of addressing significant challenges that affect societies across the world—disrupters, entrepreneurs, visionaries—are indeed change agents in every sense of the word. But large-scale problem-solving, the kind that address highly complex if not wicked problems, requires transformative thinking. What are the lessons these foundation leaders are learning about building a better world? Speakers: Peggy Clark, Xavier de Souza Briggs, Risa Lavizzo-Mourey, Sally Osberg