Just over a decade ago the face of British farming changed forever. A devastating outbreak of Foot and Mouth disease led to the enforced slaughter and incineration of over 10 million livestock across the country. While this mass culling halted the spread of disease in the UK, the fight against Foot and Mouth continues to this day, predominately in developing countries. Fortunately, cutting edge structural biology research is paving the way for a new vaccine, set to revolutionise farming on a global scale.