If you experience any technical difficulties with this video or would like to make an accessibility-related request, please send a message to [email protected]. The 2014 Rhoda G. Sarnat Lecture, “Neuroscience, Therapeutic Action, and Clinical Pragmatism: Experiments in Adapting to Need,” was given on October 24, 2014, at the University of Chicago School of Social Service Administration. The speaker was William Borden, PhD, Senior Lecturer, School of Social Service Administration. In this talk, William Borden reviews recent developments in the science of mind, showing how emerging models of development validate differing conceptions of therapeutic action across the foundational schools of thought in contemporary psychotherapy and strengthen our understanding of facilitating processes in integrative practice. Drawing on the case of an individual diagnosed with posttraumatic stress disorder, he considers core elements believed to foster neural plasticity and integration over the course of psychotherapy. Borden shows how emerging perspectives in neuroscience reaffirm the basic values and principles of clinical pragmatism, bridging scientific and humanistic domains of concern, and emphasizing the importance of comparative approaches to understanding, the practical outcomes of ideas in a given situation, and the crucial role of collaboration and experiential learning over the course of intervention. For a complete description, visit ssa.uchicago.edu/neuroscience-therapeutic-action-and-clinical-pragmatism.