Mitochondria are called the powerhouse of the cells. They convert nutrients into energy, and they may hold the key to reverse aging and cure a large number of diseases. This is why exercise is important. But, can science one day come up with a pill that can reverse the aging of mitochondria? How close are we to solve this fundamental discovery? Shortly after this interview professor Zhen Yan received the Jacobæus Prize 2022 from the Novo Nordisk Foundation for his lifetime contribution to understanding of exercise for improvement of health. The Prize comes with 1,5 mio. DKK. Professor Zhen Yan from University of Virginia was interviewed by Science Journalist Jens Degett from Science Stories.