COVID-19 has gone through a gamut of changes over the last two years. And it has been brewing in different populations much faster than other recent viruses. Further, even though viruses undergo mutation constantly, most other viruses have not managed to trigger a pandemic the way COVID did. In this episode of the Science With a Twist podcast, our host and Chief Scientific Officer at Thermo Fisher Scientific, Karen Nelson, welcomes Kamini Varma and Andy Felton. Kamini is the Vice President of Research and Development, and Andy is the Vice President of Platforms, Research, and Applied at Thermo Fisher Scientific. In this episode, they discuss the uniqueness of the SARS-CoV-2 virus, the difference between variants of concern and variants of interest, and their prediction for the future of COVID-19.