In this Science with a Twist episode, host Jami Elliott engages in a thought-provoking conversation with Jeff Shaman, Chief Scientific Officer at Coriell Life Sciences. They delve into the fascinating world of precision medicine and pharmacogenomics, exploring how these fields are revolutionizing healthcare by tailoring treatments to individual patient characteristics. Jeff illustrates the concept of pharmacogenomics, explaining how it combines pharmacology and genomics to understand how a person's genetic makeup affects their response to medications. This knowledge allows healthcare providers to prescribe the proper medication and dosage, reducing trial and error, improving treatment effectiveness, and minimizing potentially negative side effects. Jeff provides real-world examples, discussing the impact of pharmacogenomics on medications like Clopidogrel and statins. The conversation concludes with a look toward the future, discussing the potential of wearable and implantable devices in healthcare. Jeff emphasizes the importance of giving healthcare professionals more tools to react in real-time and make informed decisions about patient care. He encourages listeners to explore pharmacogenomics and consider its benefits in their healthcare journey.