Kevin Esvelt knows the stakes are high. As a geneticist at the MIT Media Lab, Kevin discovered a technique called a gene drive, which gives humans a power we’ve never had before: to change the DNA of entire species in nature. This capacity is so new and so unprecedented that when Kevin made the discovery six years ago, it was “literally unimagined by any human being at that time — not in science fiction, not in any form of literature, not in any scientific journals.” Used successfully for good, a gene drive has the potential to save millions of lives by eliminating diseases like Malaria. But in the wrong hands — or even in well-intentioned hands — the results could be catastrophic. How do we weigh the potential for enormous good against the terrifying unknowns? Host Caterina Fake thinks it through with scientist Kevin Esvelt as well as special guests Baratunde Thurston (Comedian and host of the podcasts Spit and #TellBlackStories); Janna Levin (Director of Science Programs at Pioneer Works, Columbia Professor of Astronomy) and Joi Ito (Director of the MIT Media Lab).