Today I talk with Shirley Gregor. She is a Professor Emerita at the Australian National University. Her research interests include artificial intelligence, human-computer interaction and the philosophy of science and technology. Her research has appeared in outlets including MIS Quarterly, Journal of Management Information Systems, Journal of the Association of Information Systems, International Journal of Electronic Commerce, European Journal of Information Systems and Information Technology & People.  In her career prof. Gregor was a Senior Editor for MIS Quarterly and was Editor-in-Chief for the Journal of the Association of Information Systems. She has led several large applied research projects. Prof. Gregor is Fellow of the Australian Computer Society and a Fellow of the Association for Information Systems. She was given a DESRIST Lifetime Achievement Award in 2017 for contributions to design science research in information systems and technology. And Design Science is the ongoing topic of our discussion. With prof. Gregor I talk about how she was drawn to the fundamental questions and why she wants to answer them. How she participated and made contribution to the ongoing development of design science research in IS. We also discuss the interesting court case related to design science, discuss the possible contribution of abduction, Simon's artificial science, the future of IS and much more. With this I welcome prof. Gregor.