Rick Greene, MD, Alexandra Gangi, MD, and Rupen Shah, MD, discuss the landmark articles on which management of primary appendiceal peritoneal surface malignancies are based. Drs. Gangi and Shah are authors of, “The Landmark Series: Appendiceal Primary Peritoneal Surface Malignancy." Dr. Gangi is Director or the Gastrointestinal Tumor and Cancer Regional Therapies Programs, and Associate Program Director, Complex General Surgical Oncology Program, Division of Surgical Oncology, Cedars Sinai Medical Center, Los Angeles, CA. Dr. Rupen Shah is Director, Peritoneal Surface Malignancy Program and senior staff surgical oncologist at the Henry Ford Cancer Institute, Detroit, MI.