Rick Greene, MD, and Audree Tadros, MD, MPH, FACS, discuss the BREAST-Q, a validated patient-reported outcome measure for satisfaction and quality of life after breast surgery, to determine whether patient satisfaction and quality of life differs among T4 breast cancer patients based on their decision to pursue reconstruction and the timing of reconstruction. Dr. Tadros is author of “Patient-Reported Outcome Measures in Patients with Clinical T4 Breast Cancer Treated with Mastectomy with and without Reconstruction.” Dr. Audree Tadros is the Jeanne A. Petrek Junior Faculty Chair, Memorial Sloan-Kettering Cancer Center, New York, and Assistant Attending Surgeon, Memorial Sloan-Kettering Cancer Center, New York, NY.