“Glucagon-like peptide-1 (GLP-1) agonists (also known as GLP-1 receptor agonists, incretin mimetics, or GLP-1 analogs) represent a class of medications used to treat type 2 diabetes mellitus and, in some cases, obesity. Examples of drugs in this class include exenatide, lixisenatide, liraglutide, albiglutide, dulaglutide, and semaglutide. According to the American Diabetes Association, metformin remains the preferred first-line therapy for treating type 2 diabetes. However, the addition of a GLP-1 analog should be considered in patients with a contraindication or intolerance to metformin, in patients with a hemoglobin A1c greater than 1.5% over target, or in patients who do not reach their target A1c in three months, particularly in patients with atherosclerosis, heart failure, or chronic kidney disease.” (Collins and Costello, 2023). Edwin Davila DO MS CISSN is a senior resident of Internal Medicine, TIGMER San Antonio. Medical degree from the UIWSOM San Antonio, MS Exercise Physiology Baylor University, BS Biology Baylor University, CISSN holder. TACSM Board of director, AMSSM board member. Prior US Naval Officer. Focus on obesity medicine and associated comorbidities. Guillermo Escalante, DSc, MBA, ATC, CSCS*D, FISSN: Dr. Escalante is currently the Assistant Dean and Professor of Kinesiology for the College of Natural Sciences at California State University, San Bernardino. He also performs research in the areas of sports nutrition, physique enhancement, sports medicine, and human performance where his work has been published in over 60 peer-reviewed publications and/or presented at regional, national, and international conferences for athletic training, strength & conditioning, and sports nutrition. He is currently the Vice-President of the International Society of Sports Nutrition.  About the Show We cover all things related to sports science, nutrition, and performance. The Sports Science Dudes represent the opinions of the hosts and guests and are not the official opinions of the International Society of Sports Nutrition (ISSN), the Society for Sports Neuroscience, or Nova Southeastern University. The advice provided on this show should not be construed as medical advice and is purely an educational forum. Hosted by Jose Antonio PhD Dr. Antonio is the co-founder and CEO of the International Society of Sports Nutrition, as well as the co-founder of the Society for Sports Neuroscience. Dr. Antonio has over 100 peer-reviewed publications, 16 books, and is Professor at Nova Southeastern University, Davie Florida in the Department of Health, and Human Performance.   Twitter: @JoseAntonioPhD   Co-host Anthony Ricci EdD Dr Ricci is an expert on Fight Sports and is currently an Assistant Professor at Nova Southeastern University in Davie Florida in the Department of Health and Human Performance.   Twitter: @sportsci_psyDoc