What if we could transform the planet and our relationship to it and each other by simply focusing on transforming one place at a time? Bill Reed and Regenesis Inc. contend just that: that by understanding the unique essence of a place, its history and geology as well as its social and geographical dynamics, we can regenerate that place and its surroundings as an integral part of a greater whole. Were we to do this on a city by city basis, with only 4037 cities larger than 100,000 people, and 3.5% being an average tipping point, we would need only to transform 141 cities to start a domino effect that would affect the entire planet. Through our conversation, Bill invites us to think both smaller and bigger at the same time, to recognize systems nested within systems, wholes within wholes. We are challenged to move from separateness to a rich experience of interwoven connectedness, to move into a way of being that has us be an indigenous part of the natural world.