In this sixth episode, experts discuss how vaccine development complexities often boil down to the manufacturing process and scaling up to large quantities. We take a look at how manufacturing processes are set up including the use of contract manufacturers (CMOs or CDMOs) that are largely in control of different parts of the production line. Experts also discuss the various pros and cons for the different manufacturing processes of mRNA vaccines, adenoviral vector vaccines, protein subunit vaccines and inactivated vaccines, and where bottle necks and supply delays could potentially form if stakeholders are not on their game. Ancillary material like vials and syringes will also be an important consideration when supply and demand is still unclear given that a lot of promising vaccines are not yet authorized. At the end of the day, nothing is impossible in this world filled with experienced industry players, but cooperation and collaboration might be the ultimate secret ingredient to success. Guest profiles and timestamps available at https://thecovaxfiles.com