DeepMind’s artificial-intelligence system AlphaFold has predicted the three-dimensional shape of almost all known proteins. The company’s boss Demis Hassabis tells us how the AI was able to solve what was, for decades, biology’s grand challenge. Plus, Gilead Amit, The Economist’s science correspondent, explores the significance of the breakthrough for scientists tackling neglected diseases and designing new molecules. The leap forward could be AI’s greatest contribution to biology to date, but how else could machine learning help science? Kenneth Cukier hosts. For full access to The Economist’s print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.