FATIGUE is one of a pilot's greatest threats. Most aviation trainings educate on Circadian Rhythm based on "time frames" of different hormone secretion (Cortisol and Melatonin). However, what isn't often mentioned, and studies have shown, is that cells also have a biological clock based on "time frames" of insulin levels. The combinations of these hormonal and cellular circadian rhythms play a huge role on FATIGUE mitigation. On this 4 day trip, my wake ups start during the first window of circadian low (WOCL). I talk about how I manage to get past that groggy feeling with a morning routine, and also when I eat and consume caffeine. Layovers are in Mexico City, Raleigh, and Guayaquil. Enjoy!