The biggest challenge in the transition to Industry4.0 lies in the horizontal and vertical integration of information flow within and across manufacturing organisations, and the digitalisation of the engineering processes involved.  Among the technologies and standards developed to enable this flow of information, is the compelling combination of AutomationML, OPC UA, and the Asset Administration Shell. To discuss this combination, I talked with Dr. Miriam Schleipen, the Chief Research Officer at EKS InTec GmbH where she deals with semantic interoperability in automation ecosystems based on Digital Twins and their application in automation environments. Miriam is head of the joint working group of OPC foundation and AutomationML e.V., leads the German Glossary Industrie 4.0, and participates in national and international standardization groups dealing with semantic interoperability for Industrie 4.0. Outline: ✔️ Introduction to AutomationML and its role in Industry4.0 ✔️ Why and How AutomationML Integrates with OPC UA ✔️ Fundamentals of The Asset Administration Shell ✔️ Defining an Information Model Inside an Asset Administration Shell ✔️ Interrelation of the Asset Administration Shell and the AutomationML ✔️ Software Tools for Describing Models in AutomationML  ✔️ Standardisation of the Asset Administration Shell ✔️ Benefits and Uses Cases of AutomationML, AAS, and OPC UA Combination ✔️ Best Practices for Implementing Asset Administration Shell Ecosystems ✔️ Role played by AutomationML, AAS, and OPC UA in Digital Twin Implementation ✔️ Distributed Digital Twins for Smart Manufacturing ✔️ AutomationML Association ✔️ EKS InTec GmbH