AI's potential to revolutionize healthcare requires a focus on responsible and trustworthy implementation. In this episode, Dr. David Rhew from Microsoft, along with Marcella Dalrymple and Dr. Michael Pencina from Duke Health, discuss the collaboration between Microsoft and Duke Health to explore the transformative potential of artificial intelligence (AI) in healthcare. Dr. Rhew emphasizes the importance of responsible and trustworthy AI, acknowledging its limitations and the need for operationalizing key principles. Dr. Pencina outlines four principles for trustworthy AI: prioritizing the human person, defining AI use cases, anticipating consequences, and establishing governance. Marcella Dalrymple, with her community perspective, highlights the necessity of addressing public uncertainty and mistrust regarding AI development. The partnership aims to form a Center of Excellence for trustworthy AI, focusing on collaborative efforts to align with ethical values and engage the community bidirectionally. The guests stress the importance of a robust governance system, automation for efficiency, and continuous monitoring to ensure AI's intended impact. Tune in and learn how this collaboration strives to revolutionize healthcare responsibly through AI.