In this episode, Joe dives deep into the effects of megadosing AKG (Alpha Ketoglutarate), a crucial supplement in metabolic pathways and its implications for longevity. Discover the risks and rewards as Joe recounts increasing his AKG intake to 15 times the standard dosage, leading to notable side effects such as enhanced anxiety and sleep issues.  Joe meticulously explains the biochemical transformation of AKG into glutamate and reviews strategies to counteract these negative impacts, including the use of supplements like B6 and Niacin.  He concludes by weighing the pros and cons of AKG. Tune in to learn more about AKG supplementation, its potential benefits, and how to safely navigate its use for optimal health outcomes If you're interested in learning more about how your DNA and genetics affect your health: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/