Join Jimmy today for a brand new Jimmy Makes Science Simple as he tackles the often misunderstand concept of why LDL cholesterol goes up for some people when they start eating low-carb.   “Is high LDL-C cholesterol harmful in lean mass hyper-responders?”  - Jimmy Moore In this episode, Jimmy features a study that was published in the November 2021 issue of the journal Current Developments in Nutrition entitled “Elevated LDL-Cholesterol with a Carbohydrate-restricted Diet: Evidence for a ‘Lean Mass Hyper-responder’ Phenotype’.” One of the contributing researchers on this paper is Dr. David Ludwig along with Dr. Nicholas Norwitz, Adrian Soto-Mota, Dr. Tro Kalayjian, and science-minded layperson Dave Feldman who was the one who came up with the lean mass hyper-responders hypothesis with low-carb diets that noticed the pattern of excessively high LDL-C levels despite high HDL-C, low triglycerides, and low BMI. It’s a truly fascinating paper for those of you who have experienced significant elevations in your LDL cholesterol despite spectacular numbers across the board in the rest of your lipid panel. Get the full details on this study in today’s episode! Got a new study you want Jimmy to feature on his @jimmymakessciencesimple Instagram page and on a future podcast? Email him the link to [email protected]. NOVEMBER 2021 STUDY: Elevated LDL-Cholesterol with a Carbohydrate-restricted Diet: Evidence for a ‘Lean Mass Hyper-responder’ Phenotype: https://academic.oup.com/cdn/advance-article/doi/10.1093/cdn/nzab144/6446805?login=false