Dean Lloyd Minor welcomes Carolyn Bertozzi, PhD, 2022 Nobel laureate in chemistry, professor of chemistry and director of Sarafan ChEM-H at Stanford University, for a conversation about her journey breaking barriers in scientific research. They discuss how her early passion for organic chemistry laid the foundation for her prize-winning work, and how the new field that she founded, bioorthogonal chemistry, has led to the development of better diagnostic testing and targeting for medical treatments. They also explore obstacles historically faced by women and LGBTQ scientists, the importance of fostering diversity in research labs, and how curiosity-driven discoveries can change lives for the better.