In "A Family Discussion," Dr. Osterholm and Chris Dall discuss the latest SARS-CoV-2 variant, consider the current and future challenges accessing Paxlovid, and explore new long COVID research. Dr. Osterholm also revisits last episode's discussion on changing public health guidelines and celebrates some canine heroes in the "This Week in Public Health History" segment.  Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes (Yue Zhang, PNAS)Minnesota hospitals say 65,000 days of care were avoidable if patients had somewhere to go (Jeremy Olson, Star Tribune)Have a Paxlovid Prescription? Low Cost Options Available (Minnesota Department of Health)Find COVID-19 Medications (Administration for Strategic Preparedness and Response, HHS)Homeless man leaves puppies at N.C. shelter with heart-tugging note (Cathy Free, Washington Post)