On this special episode of The Raw Nerve podcast, recorded at the 2023 Progress in MS Research Conference in Perth, we take a deep dive into PLATYPUS, Australia's groundbreaking adaptive clinical trial for progressive MS. Dr Julia Morahan, Head of Research at MS Australia, guides us through a captivating discussion with the brilliant minds steering PLATYPUS—Professor Jeremy Chataway of University College London, Chief Investigator of the UK's OCTOPUS trial, and Professor Simon Broadley from Griffith University, overseeing PLATYPUS. Hear the fascinating story behind PLATYPUS's genesis and how it could reshape the future of progressive MS treatment. The discussion goes into the origins of PLATYPUS and the advantages of its innovative multi-arm, multi-stage trial design, along with the pivotal role played by the MS Community in shaping and overseeing the trial. As we conclude, our guests share their ultimate dreams of what PLATYPUS and OCTOPUS could ultimately achieve. Useful link: PLATYPUS