In the first episode of 2024, Shobita and Jack reflect on the first CRISPR therapy approved by drug regulators around the world, for sickle cell disease. We also talk about the safety issues plaguing Boeing, and the Post Office scandal roiling the UK and why it matters for regulating AI. And, we reconnect with Alondra Nelson, one of The Received Wisdom's first guests! Alondra Nelson is the Harold F. Linder Professor at the Institute for Advanced Study and previously as deputy assistant to President Joe Biden and acting director of the White House Office of Science and Technology Policy (OSTP).