Paradigm-shifting knowledge continues to reshape our approach to cancer prevention, diagnosis, and treatment. We are going deeper into cancer genomics and the heterogeneity of malignancy, developing new immunotherapies that build on the body’s natural defenses, and designing targeted drugs that block cancer pathways. In forward-facing clinics and hospitals, design that abets healing is gaining new attention. Bringing the best science into under-resourced communities remains an enormous challenge, but state-of-the-art cancer facilities in Rwanda and Uganda offer models the world can learn from. What’s on the horizon in cancer research and clinical care? Will the ceaseless war on cancer ever end in victory? How do we share advances more equitably around the globe?