In this episode, Drs. Fiona Watt and Alice Vickers join the podcast to talk about uncovering the relationship between genetic variants and cellular behavior. They recently developed a platform to quantify iPSC differentiation propensity to investigate the genetic contribution to phenotypic variability. Drs. Vickers and Watt are authors of the recent paper,  "Plating human iPSC lines on micropatterned substrates relevels role for ITGBI nsSNV in endoderm formation” in Stem Cell Reports.  Guests Fiona Watt, DPhil, Centre for Stem Cells and Regenerative Medicine, King’s College London Website: http://www.wattlab.org/  Alice Vickers, PhD, INKEF Capital, Amsterdam (current affiliation). Centre for Stem Cells and Regenerative Medicine, King’s College London (previous affiliation). Website: https://www.inkefcapital.com Supporting Document ”Plating human iPSC lines on micropatterned substrates relevels role for ITGBI nsSNV in endoderm formation”  Host Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory Twitter: @martinperaJAX About Stem Cell Reports Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians. Twitter: @StemCellReports About ISSCR With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.  Twitter: @ISSCR Acknowledgements ISSCR Staff Keith Alm, Chief Executive Officer Bethany Almon, Senior Manager of Integrated Marketing Yvonne Fisher, Managing Editor, Stem Cell Reports Kym Kilbourne, Director of Media and Strategic Communications Jack Mosher, Senior Manager of Scientific Affairs Voice Work Ben Snitkoff Music @Konovalov