In this episode of the Stem Cell Report, Martin Pera is joined by a team of scientists from the Neural Stem Cell Institute in Rensselaer, NY, USA.  Drs. Elizabeth Fisher, Xiuli Zhao, and Institute Director Sally Temple talk about their new paper on neural stem and progenitor cell function in the aging adult brain. They use live time-lapse imaging with computer-based image analysis to assess young and aged neural stem and progenitor cells in 3D brain structures to assess the mechanism underlying changes to the aging brain.  Guests Sally Temple, PhD, Neural Stem Cell Institute Xiuli Zhao MD, PhD, Neural Stem Cell Institute Elizabeth Fisher, PhD, Neural Stem Cell Institute  Host Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory Twitter: @martinperaJAX Read Their Paper 4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway  About Stem Cell Reports Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians. Twitter: @StemCellReports About ISSCR With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health. Twitter: @ISSCR Acknowledgement ISSCR Staff Keith Alm, Chief Executive Officer Bethany Almon, Senior Manager of Integrated Marketing Yvonne Fisher, Managing Editor, Stem Cell Reports Kym Kilbourne, Director of Media and Strategic Communications Jack Mosher, Scientific Advisor Voice Work Ben Snitkoff Music @Konovalov