“I loved the interview with Donna Jackson Nakazawa about the intersection of psychoneuroimmunology, trauma and microglia. I am stoked to read her book! However; about halfway through Laura mentions something about autoimmune disorders being more common in female identified patients. They are actually more common in patients with two X chromosomes / identified as female at birth (or Klinefelter’s syndrome or other XX intersex condition) because many genes relating to the immune system are stored on the portion of the X chromosome which is missing in Y. Gender identity has no apparent impact. These x-linked recessive autoimmune genotypes are why people with XY chromosomes (cis men and most trans women) are less prone to autoimmune disorders, but more likely to die of infectious disease (and younger) than cis women and trans men, their xx counterparts. One of the ways we have confirmed this is causative rather than correlative is that trans men, non-binary people and trans women retain the likelihood of developing said disorders associated with their chromosomal sex even after going through hormonal transition (though esterol and estradiol are also theorized to have an additional inflammatory effect partially mitigated by progesterone hence the relationship between menstrual cycle and flareups, and between aromatization and autoimmunity the case of a higher-testosterone system).”
peterpinkpuss via Apple Podcasts ·
United States of America ·
06/19/22