AI may be the most consequential technology advance of our lifetime. Rapid advances are creating new opportunities, challenges, and questions that require the public and private sectors to come together to ensure that this technology serves the public good. In this special episode, recorded as part of an event hosted by Microsoft in Washington D.C., I share how AI is leading to new breakthroughs in research, healthcare, and productivity, the guardrails required to ensure accountability and transparency, and a five-point blueprint to help create AI Policy, Law, and Regulation.