This piece is a discussion which followed three presentations at the Evidence Based Perioperaive Medicine (EBPOM) World Congress in London on artificial intelligence in perioperative medicine. Although, for an informed listener, it will work as a standalone piece the presentations which it is in part a response to are here: Part one is here: https://topmedtalk.libsyn.com/ai-in-perioperative-care-part-1-ebpom-london-2023 Part two is here: https://topmedtalk.libsyn.com/artificial-intelligence-in-perioperative-care-part-2-ebpom-2023 Part three is here: https://topmedtalk.libsyn.com/ai-predictive-monitoring-to-prevent-hemodynamic-instability-and-deterioration-in-perioperative-and-acute-care-patients-ebpom-world-congress On the panel are; Feras Hatib, Vice President of the R&D Algorithms and Signal Processing organization for Critical Care and Vascular at Edwards Lifesciences in Irvine California, Adriane Chapman, Professor at University of Southampton, Head of Digital Health Research Group, Director for the Centre for Health Technologies and Sandy (Alexander) Jackson, specialty trainee in anaesthetics and intensive care medicine and a National Institute for Health and Care Research (NIHR) Doctoral Fellow at the University of Southampton. This piece is chaired by TopMedTalk’s co-editor in Chief Mike Grocott, Professor of Anaesthesia and Critical Care Medicine at the University of Southampton.