It's easier to move upmarket than down. We look at why this gives SaaS startups the advantage against incumbents and how to price for the move.
Published 05/29/20
Today’s episode is about a practical application of crypto — namely, the way it can “tokenize” fandom. More broadly, it’s about fan engagement, and the increasingly blurred lines between sports, culture and tech.  We talked to NBA player Spencer Dinwiddie, of the Brooklyn Nets. Spencer created a new platform on the crypto blockchain Ethereum that gives fans the opportunity to invest directly in his revenue-generating potential, through debt securities.  Joining this conversation are a16z...
Published 05/26/20
with @PascaStanford, @VijayPande, and @omnivorousread Our understanding of the human brain and its disorders has always been limited by our lack of access to living, human, developing brain tissue. For the first time, that's changing. In this episode, Sergiu Pasca, Professor of Behavioral Science at Stanford, talks with a16'z General Partner Vijay Pande and Hanne Tidnam about the wild new tech that's pioneering a whole new approach to understanding the brain: brain organoids. This...
Published 05/24/20
with @nachristakis @jorgecondebio Going from rapid warning to early detection through social network sensors can make all the difference when it comes to contagion/ the spread of disease and pandemics. Can we get public health bio surveillance without sacrificing privacy and agency?
Published 05/23/20
with @nwquah @conniechan and @smc90 This (rerun) podcast is a podcast about podcasting: But it's really all about audio...
Published 05/20/20
In normal times, every company operates against some hypothetical growth model—a data-driven framework that describes how your product grows and how you acquire new users. These, of course, are not normal times. In the fallout from the pandemic, most founders and CEOs are in the process of completely revamping their growth models from the bottom up amid new and unpredictable consumer behavior. This episode explores how to think about growth in turbulent times, according to two growth experts:...
Published 05/15/20
with @vijaypande, @andy23tran, and @lr_bio a16z Journal Club covers a new approach for preventing coronavirus and influenza infection using the genome editing platform CRISPR-Cas.
Published 05/15/20
John Riccitiello, CEO of the game software development company Unity Technologies, discusses the rise of esports and streaming, the potential of cloud gaming, and far-reaching applications for game technology.
Published 05/07/20
with @jaybrander, @JorgeCondeBio, @omnivorousread A deep dive into the world of drug development—specifically "undruggable drugs": a category of protein, protein family or even piece of RNA that’s so difficult to target that many researchers don’t even want to touch it—with Jay Bradner, President of the Novartis Institute for BioMedical Research.
Published 05/06/20
This episode—which originally took place as a live event—is a conversation between Seattle Seahawks linebacker Bobby Wagner and a16z Cultural Leadership Fund partner Chris Lyons.
Published 05/02/20
As the responsibility of CSOs has expanded, the role has moved from technical IT to the boardroom. How do the best CSOs prepare for and respond to a crisis, from redteaming to comms? What responsibility should cloud & SaaS vendors, not to mention the government, have in security and data breaches?
Published 04/29/20
Published 04/29/20
with @vijaypande @andy23tran @heyjudka @lr_bio a16z Journal Club covers recent advances from the scientific literature; this inaugural episode for bio covers 2 two different topics: (1) identifying new antibiotics through a novel machine-learning based approach; and (2) characterizing the novel coronavirus causing the COVID-19 pandemic
Published 04/26/20
Announcing a16z Journal Club, a new show where we curate and discuss recent research papers with a16z experts and others. The first episode is of bio journal club, which focuses on why specific scientific advances matter from our perspective at the intersection of biology & technology.
Published 04/26/20
Today’s episode is one of our intimate hallway-style conversations — or as intimate as remote work allows anyway. It’s all about the history and future of protocol development. a16z crypto partner Ali Yahya, formerly Distributed Systems & Machine Learning researcher at Stanford & Google Brain, wrote a tweetstorm earlier this year about the “Narrow Waist of Blockchain Computing” (we link to in the show notes). Ali observed that the Internet Protocol, which emerged out of research...
Published 04/24/20
@pmarca reads out loud IT'S TIME TO BUILD
Published 04/21/20
an announcement about a new, occasional series of posts from us, read out loud here
Published 04/21/20
Patreon cofounder Sam Yam and a16z partner Li Jin join host Lauren Murrow to talk about the Passion Economy: online platforms that enable people to make a living off their unique interests and skills. It's a trend that's become increasingly relevant as unemployment spikes and the demand for virtual work grows.
Published 04/18/20
a16z General Partners Jorge Conde and Julie Yoo talk with Hanne Tidnam about some of those big forces and dynamics in the healthcare system, at the intersection of business, policy, and public health: how in healthcare like perhaps nowhere else, broken policy can lead to broken business models that, in the wrong circumstances, can then lead major failures in public health like the one we’re seeing today; where we’ve seen this before, in the markets of vaccines, antibiotics, and diagnostics;...
Published 04/16/20
Will remote work be our new reality, even after the pandemic passes? And if so, what are the current technologIes and practices that support organizational communication and alignment for distributed teams, development and otherwise?
Published 04/15/20
Dr. Bobby Green, MD (Community Oncologist and Chief Medical Officer, Flatiron Health) and Dr. Sumit Shah (Oncologist and Head of Digital Health, Stanford Cancer Center) join a16z's Vineeta Agarwala (physician and general partner) and Hanne Tidnam to talk about what is happening to oncology during the outbreak—how treatment is affected; what kind of clinical decisions oncologists and patients are having to make, and how they're making them; the tech tools that specialists are using, and how...
Published 04/10/20
In this episode, we dive into the remarkable story of one American family, the Galvins: Mimi, Don, and their 12 children, 6 of whom were afflicted with schizophrenia. In Hidden Valley Road: Inside the Mind of an American Family, Robert Kolker follows the family from the 1950s to today, through, he writes, "the eras of institutionalization and shock therapy, the debates between psycho-therapy versus medication, the needle-in-a-haystack search for genetic markers for the disease, and the...
Published 04/07/20
For any business, there are three core financial statements – the income or P&L statement, the balance sheet, and the cash flow statement. While these statements can show investors and the board how the business is doing, they can do more than just keep score on your business – they are one of the best tools you have to run it, especially in times of crisis.
Published 04/04/20
Since social distancing measures were first put in place, time spent gaming has gone up—way up. According to a recent report by Verizon, video game usage in the U.S. has risen 75 percent during peak hours. The "stay at home" movement has given way to an upswell of new and returning gamers—as well as new challenges, as online platforms struggle to keep up with the surge. In this episode, a16z partner Jon Lai joins host Lauren Murrow to talk about how game developers are grappling with...
Published 04/02/20
A robot lawyer that helps people automatically fight bureaucracy to get money back, find hidden money, or sue others/ go to small claims court. Also now helps people delay utility bills and rent payments that are eligible for an extension or waiver of late fees due to the coronavirus crisis. with @jbrowder1 @bhorowitz @shakasenghor
Published 04/01/20